By Ashutosh Tiwari, Bora Garipcan, Lokman Uzun
The booklet outlines first the significance of additional mobile Matrix (ECM), that's a traditional floor for many of cells. within the following chapters the effect of organic, chemical, mechanical, and actual homes of surfaces in micro and nano-scale on stem mobile habit are mentioned together with the mechanotransduction. Biomimetic and bioinspired techniques are highlighted for constructing microenvironment of a number of tissues, and floor engineering purposes are mentioned in tissue engineering, regenerative medication and diverse form of biomaterials in a variety of chapters of the book.
This booklet brings jointly leading edge methodologies and techniques followed within the examine and improvement of Advanced Surfaces in Stem telephone Research. recognized around the world researchers planned matters including:
- Extracellular matrix proteins for stem mobile fate
- The superficial mechanical and actual homes of matrix microenvironment as stem phone destiny regulator
- Effects of mechanotransduction on stem cellphone behavior
- Modulation of stem cells habit via bioactive surfaces
- Influence of managed micro and nanoengineered surfaces on stem phone fate
- Nanostructured polymeric surfaces for stem cells
- Laser floor amendment thoughts and stem cells applications
- Plasma polymer deposition: a flexible software for stem cellphone research
- Application of bioreactor thought and modeling concepts in bone regeneration and augmentation treatments
- Substrates and surfaces for keep an eye on of pluripotent stem phone destiny and function
- Application of biopolymer-based, floor changed units in transplant medication and tissue engineering
- Silk as a common biopolymer for tissue engineering
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Extra resources for Advanced Surfaces for Stem Cell Research
New emerging potentials for human Wharton’s jelly mesenchymal stem cells: immunological features and hepatocyte-like differentiative capacity. Stem Cells Dev. 19, 423–38, 2010. 7. , et al. Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells. Stem Cells Dev. 17, 1095–107, 2008. 8. , Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663–76, 2006. 9. , A review on extracellular matrix mimicking strategies for an artificial stem cell niche.
Cells stretched multidirectionally to follow underlying 283 nm fibers but when grown on larger fibers, extended along a single fiber axis. 1 Changes in morphology and proliferation of human mesenchymal stem cells (hMSCs) cultured on nanogratings. Scanning electron micrographs (SEM) of (a) PDMS nanopatterned by replica molding; hMSCs cultured on (b) nanopatterned PDMS and (c) unpatterned PDMS. Adapted from Yim EK et al. . 2) [56, 61]. So, fiber diameter in electrospun scaffolds and pore size and pore distribution in porous scaffolds is important.
2010, 120623, 2010. 34. S. How cells sense extracellular matrix stiffness: a material’s perspective. Curr. Opin. Biotechnol. 24, 948–53, 2013. 35. , et al. Matrix cross-linking forces tumor progression by enhancing integrin signaling. Cell 139, 891–906, 2009. 36. , et al. Extracellular-matrix tethering regulates stem-cell fate. Nat. Mater. 11, 642–9, 2012. 37. , et al. A role for matrix stiffness in the regulation of cardiac side population cell function. Am. J. Physiol. Heart. Circ. Physiol. 308, H990–7, 2015.