By Jeffrey P. Jones (auth.), Adnan Elfarra (eds.)

I have consistently been drawn to chemistry and biology. My undergraduate, graduate, and postdoctoral trainings in pharmacy, medicinal chemistry and pharmacology, respectively, have reinforced this curiosity and led me to achieve that major advances in drugs have usually been learned as a result of examine on the chem- try–biology interface. i hope that this accomplished quantity on fresh advances in bioactivation examine will stimulate pharmacologists, medicinal chemists, phar- ceutical scientists, and graduate scholars in those fields and similar parts to think about and use bioactivation examine after they discover and chart new frontiers in drug layout and drug improvement and once they give some thought to how one can lessen the negative effects of latest medicinal drugs by means of making prodrugs. As for the toxicologists and environmental well-being scientists, i am hoping this quantity can help them generate the information had to comprehend higher mechanisms of toxicity to enhance human threat tests and intervention equipment after occupational or environmental publicity to numerous dangerous chemical compounds. Adnan A. Elfarra, Ph. D. vii half I common options and simple Mechanisms 1 Metabolic issues in Drug layout Jeffrey P. Jones division of Chemistry, Washington country collage, Pullman, WA 99164, united states e mail: jpj@wsu. edu key phrases: Cytochrome P450 Aldehyde Oxidase Drug–Drug Interactions Mechanism-based digital Screening ADMET Regioselectivity 1. 1. creation as a result of contemporary technological strategies, resembling genomics, combinatorial chemistry, and high-throughput screening, the id of disorder pursuits and of compounds which are lively opposed to those goals (‘‘leads’’) can now be performed efficiently.

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Inorg. Chem. 9:644–653. Jones, J. P. 2004. Metabolic menages a trois: what does it mean for drug design? Drug Discov. Today 9:592–592. Jones, J. , Korzekwa, K. , Rettie, A. , and Trager, W. F. 1986. Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P450 catalyzed reactions: a new method for the estimation of intrinsic isotope effects. J. Am. Chem. Soc. 108:7074–7078. Jones, J. , and Korzekwa, K. R. 2002. Computational models for cytochrome P450: a predictive electronic model for aromatic oxidation and hydrogen atom abstraction.

Chem. Rev. 105: 2279–2328. Sharma, P. , De Visser, S. , and Shaik, S. 2003. Can a single oxidant with two spin states masquerade as two different oxidants? A study of the sulfoxidation mechanism by cytochrome p450. J. Am. Chem. Soc. 125:8698–8699. , Roberts, E. , and Hollenberg, P. F. 1996. Formation of a metabolic intermediate complex of cytochrome P4502B1 by clorgyline. Drug Metab. Dispos. 24:1247–1253. Singh, S. , Shen, L. , Walker, M. , and Sheridan, R. P. 2003. A model for predicting likely sites of CYP3A4-mediated metabolism on drug-like molecules.

Grimm, S. , Andersson, T. , Zauhar, R. , and Zamora, I. 2006. Comparison of methods for the prediction of the metabolic sites for CYP3A4-mediated metabolic reactions. Drug Metab. Dispos. 34: 976–983. 2 Role of Bioactivation in Idiosyncratic Drug Toxicity: Structure–Toxicity Relationships Amit S. 1. Adverse Drug Reactions Adverse drug reactions (ADRs) continue to be a significant contributor to overall attrition statistics in the pharmaceutical industry. ADRs pose a significant health problem since they contribute to patient morbidity and mortality and represent one of the most common causes for pharmaceutical product recalls and black-box warning labels.

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