By Peter McLaughlin, Lester E. Robertson, Michael J. Keating (auth.), Fernando Cabanillas M.D., M. Alma Rodriguez M.D. (eds.)

Fernando Cabanillas In 1993, Fisher et al. released the result of a randomized trial evaluating 3 third-generation regimens opposed to the vintage CHOP blend. For a number of years, the oncology neighborhood were confident that the 3rd­ iteration regimens have been basically improved to cut. It got here as a surprise to many who there has been no distinction in end result among the 4 fingers of this medical trial. The logical end is that CHOP is nearly as good as any of the opposite regimens verified in that examine. regrettably, this wonderful research has been misinterpreted by way of many as proving that there has no longer been any growth within the box of lymphoma over the last two decades. moreover, it has resulted in a fatalistic perspective within the reasoning of many clinicians who believe that 'nothing works higher than CHOP' and consequently that it's not worthy checking out new medicinal drugs or constructing novel regimens. besides the fact that, the method in which we stream ahead within the oncology box is seldom through dramatic breakthroughs. often, what seems before everything look to be a leap forward seems later to be only a modest leap forward. a number of steps ahead ultimately upload as much as a massive improve, yet this improve is going overlooked as a result gradual nature of the method. during this quantity, we have now selected to debate a number of of those steps, which we consider are basically creating a confident influence at the box of lymphomas and which quickly should still make an immense distinction in healing results.

Show description

Read or Download Advances in Lymphoma Research PDF

Best research books

Legal Ontology Engineering: Methodologies, Modelling Trends, and the Ontology of Professional Judicial Knowledge

Allowing details interoperability, fostering criminal wisdom usability and reuse, improving felony info seek, briefly, formalizing the complexity of felony wisdom to reinforce criminal wisdom administration are not easy projects, for which various ideas and features of study were proposed.

The SAGE handbook of qualitative research in psychology

This instruction manual covers the qualitative tools utilized in psychology combining 'how-to-do-it' summaries with exam of old and theoretical foundations. Examples from fresh learn are used to demonstrate how each one approach has been utilized, the knowledge analysed and the insights won. content material: part I.

Formulating Research Methods for Information Systems: Volume 1

This edited two-volume assortment offers the main attention-grabbing and compelling articles touching on the formula of study equipment used to review info structures from the 30-year book heritage of the magazine of knowledge know-how .

Extra resources for Advances in Lymphoma Research

Sample text

7. Juliusson G, Liliemark J (1993). High complete remission rate from 2-chloro-2'deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count. J Clin Oncol11:679-689. 8. Kay AC, Saven A, Carrera CJ, Carson DA, Beutler E, Piro LD (1992). 2Chlorodeoxyadenosine treatment of low-grade lymphomas. J Clin OncoI10:371-377. 9. Hoffman M, Tallman M, Hakimian D, et al. (1994). 2-Chlorodeoxyadenosine is an active salvage therapy in advanced indolent non-Hodkin's lymphoma.

A 35 100 -, ! ,: 80 .. -----: ! 50 J lic-----: ,, , 40 *-1-1----------------1------- ------------1 30 20 TDTAl 22 21 10 0 0 • DEATHS 5 Grad. I • Grid. II 144 182 Months 218 338 Figure 7. Estimated survival of stage I, II NSHD by grade. At 10 years, approximately 86% NSHD I and 45% NSHD II patients were alive. study by Ferry et al. of 79 patients showed 27% of the patients to have NSHD II [24]. Our study deliberately attempted to analyze an equal number of NSHD I and NSHD II cases, and thus we did not calculate the portion of NSHD II cases in a random series [20,21].

Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice. Cancer Res 49:4972-4978. 22. Giblett ER, Anderson JE, Cohen F, Pollara B, Meuwissen HJ (1972). Adenosine deaminase deficiency in two patients with severcly impaired cellular immunity. Lancet 2:1067-1069. 23. Cohen A, Hirshhorn R, Horowitz SD, et al. (1978). Deoxyadenosine triphosphate as a 24 24. 25. 26. 27. 28. 29. 30. 31.

Download PDF sample

Rated 4.63 of 5 – based on 46 votes