By Kinam Park
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Extra info for Biomaterials for cancer therapeutics: Diagnosis, prevention and therapy
2013). This hyperthermal approach is expected to work well, at least in theory, but it still faces many hurdles. , 2004; Qiu and Park, 2012). The nanoparticulate formulations usually have a drug loading level of 20% or less. One apparent improvement to be made is to increase the drug loading to higher values. , 2011). The content of a drug in drug crystals is very high. Even if the drug crystals are covered with a polymer layer for further surface modification, the drug content will be still very high.
D. N. Waterhouse, L. D. Mayer, P. R. Cullis, T. D. Madden and M. B. Bally (2005). The liposomal formulation of doxorubicin. Method Enzymol 391, 71–96. , D. Tesauro and G. Morelli (2013). Peptide-based targeting strategies for simultaneous imaging and therapy with nanovectors. Polym J 19, 1–13. Acharya, S. and S. K. Sahoo (2011). PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect. Adv Drug Deliv Rev 63(3), 170–183. , M. A. Mackey, M. A. El-Sayed and R. V.
Bolkestein, A. Gasselhuber, J. Yatvin, G. C. van Rhoon, A. M. Eggermont, D. Haemmerich and G. A. Koning (2013). Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia. J Control Release 167(2), 130–137. Loos, W. , S. D. Baker, J. Verweij, J. G. Boonstra and A. Sparreboom (2003). Clinical pharmacokinetics of unbound docetaxel: Role of polysorbate 80 and serum proteins. Clin Pharmacol Ther 74(4), 364–371. , S. C. Owen and M. S. Shoichet (2011). Stability of self-assembled polymeric micelles in serum.