By Giuseppe Perale, Jöns Hilborn
Bioresorbable Polymers for Biomedical purposes: From basics to Translational Medicine offers readers with an outline of bioresorbable polymeric fabrics within the biomedical box. an invaluable source for fabrics scientists in and academia, supplying info at the basics and concerns, synthesis and processing, and the medical and R and D functions of bioresorbable polymers for biomedical applications.
- Focuses on biomedical purposes of bioresorbable polymers
- Features a finished variety of subject matters together with basics, synthesis, processing, and applications
- Provides balanced assurance of the sphere with contributions from academia and industry
- Includes medical and R and D functions of bioresorbable polymers for biomedical applications
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Extra info for Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine
This technique is normally applied in already packaged products because of the high penetration power and the modest increase in temperature (<5 C), but it promotes the cleavage of 14 Bioresorbable Polymers for Biomedical Applications polymers chains, causing a reduction in molecular weight. Thus, it is necessary to evaluate the ﬁnal application, in primis, from a mechanical point of view. Another solution is the beta radiation (high-speed electrons), which is less aggressive than gamma radiation, but the kind of packaging limits this application due to the low penetration power.
The biocompatibility of polymers is deﬁned by the degradation products. In fact, polymers may reduce the local pH, thereby affecting the integrity of the cells in their microenvironment. Adopting new 6 Bioresorbable Polymers for Biomedical Applications materials or a combination of well-known polymers needs a deep evaluation of biocompatibility and toxicity by using speciﬁc tests described by the American Society for Testing and Materials standards, the US Pharmacopeia, and the International Organization for Standardization (ISO 10993) (Dang, 1996).
Although its relatively low melting point limits its structural applications, its excellent blending properties allow it to be blended with poly(vinyl chloride) to produce materials with higher melting points. Karal et al. (1997) have reported that PCL and PVC are compatible over a wide range of compositions. Furthermore, with its signiﬁcant degree of crystallinity and substantial hydrophobicity, high-molecular-weight PCL has shown remarkably long in vivo degradation times (Pernin, 1997). As an aliphatic polyester, PCL also degrades by hydrolysis, and the hydrolyzed products are reabsorbed by the body with minimal reaction of the tissues.